Tranexamic acid

Tranexamic acid is a substance that inhibits the action of an enzyme known as plasminogen, which normally binds to clots to destroy them and prevent them from forming a thrombosis, for example. However, in people with diseases that make the blood too thin, plasminogen can also prevent clots from forming during cuts, for example, making it difficult to stop bleeding.

In addition, this substance also appears to prevent normal melanin production and, therefore, can be used to lighten some skin blemishes, especially in the case of melasma.

Due to its double action, this substance can be found in the form of pills, to prevent bleeding, or in the form of cream, to help lighten stains. It can also be used as an injectable in the hospital, to correct emergencies related to excessive bleeding.

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The price of tranexamic acid can vary between 30 to 60 reais, for the tablets, depending on the commercial name and place of purchase. The most used trade names are Transamin or Trexacont.

In the form of cream, the average value is 40 reais, for about 30 grams.

What is it for

This substance is indicated for:

  • Reduce the risk of bleeding during surgery;
  • Lighten melasmas and dark spots on the skin;
  • Treat bleeding associated with excessive fibrinolysis.

The use of this substance in the form of tablets to treat or prevent the appearance of bleeding should only be done after a doctor’s recommendation.

How to use

The dose and time of use of this medication should always be guided by the doctor, however the general indications are:

  • Treat or prevent bleeding in children : take 10 to 25 mg / kg, two to three times a day;
  • Treat or prevent bleeding in adults : 1 to 1.5 grams, two to four times a day, for about 3 days. Or 15 to 25 mg / day if the treatment lasts more than 3 days;
  • Lighten skin stains : use a cream with a concentration between 0.4% and 4% and apply it to the area to lighten. Apply sunscreen during the day.

The dose of the pills may be adequate, by the doctor, according to the patient’s history, use of other medications and the effects presented.

Possible side effects

The most common side effects include nausea, vomiting, diarrhea and a marked decrease in blood pressure.

Who should not use

Tranexamic acid should not be used in people with hemophilia undergoing treatment with another drug, in patients with intravascular coagulation or with the presence of blood in the urine. In addition, it should also be avoided for thoracic or abdominal surgeries, as there is a greater risk of bruising.

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